Ketamine for Substance Use Disorder


Reduce Cravings

Ketamine has been found helpful in the treatment of many forms of substance use disorders (SUDs), including alcoholism, opioids, stimulants, marijuana, and cocaine addictions.

Ketamine for the treatment of addictions is still in the experimental stage and is considered “off-label use” by the FDA. However, research has shown promising results and is continuing to evolve.

While still experimental, research has shown that ketamine can help change how your brain deals with cravings, improve motivation to quit, and can smooth out the ups and downs common in the first stages of recovery. Ketamine treatment might also make therapy more effective, increasing your likelihood of success.

Avoid Relapse

Studies suggest that ketamine can lessen the chance of restarting addictive substances or relapsing into addictions

How ketamine works to treat addictions

While research is ongoing, studies indicate several ways that ketamine works in the treatment of substance use disorders.

Ketamine blocks the NMDA receptor, which, through a chain of events, helps regulate mood and is also important in the formation of memories. By disrupting the memory pathways (it does not cause memory loss), ketamine can weaken or even eliminate common triggers that cause addiction.

Ketamine regrows and strengthens neurons, helping forge new pathways that are essential to the formation of new memories and thought processes, helping reduce cravings and relapse. And the best part? This process could help improve and enhance the effects of therapy and help treat the issues that caused the addiction in the first place.


One-year alcohol abstinence rates following inpatient treatment and ketamine infusions.


One-year heroin abstinence rates following three ketamine + therapy sessions.

Substance Use Disorder research

Level of evidence
Magnitude of effect
Substance Use Disorders
Seven studies were reviewed (2-alcohol, 2-cocaine, 3-opiods). Improvements in craving, motivation, and use were noted for cocaine, improved two-year abstinence rates for alcohol and opioids after a single infusion.
Alcohol Withdrawl
Ketamine reduced benzodiazepine requirements for acute withdrawal syndrome (AWS) and is well tolerated at low doses.
Opiod Withdrawl
Case study for management of opioid withdrawal in a woman with chronic pain. Patient dramatically reduced opioid use without any withdrawal symptoms.
Opiod Withdrawl
Two case reoprts for treatment of opioid withdrawal symptoms. "The use of intravenous ketamine can be considered as a bridge to successful initiation of buprenorphine to wean the patient off from high opioid doses while providing adequate analgesia turing the transition period".

"This place saved my life. The staff is always so welcoming and friendly, as well as supportive and accommodating. Because of these infusions I’ve been able to get my life back in control. Thank you

– Adelle P

Treatment options for substance abuse

Ketamine + Therapy

Work through challenging life issues with Ketamine Assisted Psychotherapy, our most involved program, with a licensed mental health counselor trained in psychedelic therapy

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